| abstract |
A HIV-1 protease inhibitor which includes an N-terminal cycle (A) or a C-terminal cycle (B) or both cycles (A) and (B) wherein Y is selected from side chains of Asn or Ile or Val or Glu and alkyl of 1-6 carbon atoms inclusive of linear or branched chains as well as cycloalkyl; and X is selected from (CH2)n where n = 3-6, -CH(OH)-CH(OH)-CH2-, CH(CO2H)-CH2-CH2, CH2CONHCHR where R = D or L amino acids and alkyl of 1-6 carbon atoms inclusive of linear or branched chains. |