| abstract |
A compound of formula (I), wherein R1 is a C¿1-6? straight or branched chain alkyl group, a C2-6alkenyl group, a C2-6alkynyl group, a C3-6cycloalkyl group or a C3-6cycloalkyl C1-6alkyl group, each optionally substituted by one to three groups independently selected from: -CN; -NO2; a group -COR?2¿ wherein R2 is hydrogen, C¿1-6?alkyl, -OR?3¿ wherein R3 is hydrogen or C¿1-6?alkyl, or NR?4R5¿, wherein R?4 and R5¿ are independently selected from hydrogen or C¿1-6?alkyl; a group -S(O)mR?6¿, wherein m is 0, 1 or 2, R6 is hydrogen, C¿1-6? alkyl, hydroxy or NR?7R8¿, wherein R?7 and R8¿ are independently hydrogen or C¿1-6? alkyl; a group PO(OR?9)¿2, wherein R9 is hydrogen or C¿1-6? alkyl; a group NR?10R11¿, wherein R?10 and R11¿ are independently selected from hydrogen, C¿1-6? alkyl, -COR?12¿, wherein R12 is hydrogen or C¿1-6?alkyl, or -S(O)m'R?13¿, wherein m' is 0, 1 or 2 and R13 is hydrogen or C¿1-6?alkyl; halo; or a group -OR?14¿, wherein R14 is hydrogen, C¿1-6? alkyl optionally substituted by one to three halo atoms, C6-10 aryl or -COR?15¿ wherein R15 is hydrogen or C¿1-6? alkyl; p is 2 or 3, q is 1 or 2 and n is 0 or 1 and all salts, esters, amides and physiologically acceptable prodrugs thereof; pharmaceutical uses and formulations therefor; and processes for their preparation are disclosed. |