| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_61f88efcda59d7062a4252ecf6886f58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bc2b03342511abc88f60c63f2acd96d0 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6858
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6827
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6809 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
1994-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb21d06934cbd5d5642bfb6b759d206a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b1d4c8815dca4ca51e6a5e075dc58064 |
| publicationDate |
1995-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-9501453-A1 |
| titleOfInvention |
A heteroduplex mobility assay for the analysis of nucleic acid sequence diversity |
| abstract |
Heteroduplexes formed between different members of a gene family migrate more slowly in non-denaturing polyacrylamide gels (PAGE) than homoduplexes. Heteroduplexes with deletions/insertions as small as a single nucleotide are identified by a mobility retardation in PAGE. Heteroduplexes containing only mismatches also display a mobility shift whose magnitude depends on the % sequence divergence. Mobility shifts of deletion/insertion heteroduplexes are affected by the size, location and number of deletions/insertions and by the sequence of the unpaired and neighboring mismatched nucleotides. The heteroduplex mobility assay (HMA) and heteroduplex tracking assay (HTA) of the present invention can be used for tracking viral quasispecies evolution within and between individuals, for tracking species of infectious agents, and for monitoring DNA sequence changes including identification and tracking of cellular DNA polymorphisms. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6994958-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03001176-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2190877-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7935480-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9720070-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2435326-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2190877-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7402382-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03001176-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0024935-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0024935-A2 |
| priorityDate |
1993-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |