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filingDate 1993-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_54c24365642b9e799d6ad53596cb82cc
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publicationDate 1994-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-9416065-A1
titleOfInvention Producing cells for transplantation to reduce host rejection and resulting cells
abstract A method for treating cells with E19 protein in order to alter the presentation of MHC class I cell surface antigens on these cells and thereby allow introduction of these cells into a recipient organism while reducing transplant rejection by the recipient organism's immune system is described. The cells may be contacted with E19 protein by the presence in the cells of a vector which carries and expresses the E19 coding sequence or by the presence in the cells of a transgene with expresses the E19 coding sequence. The method may be used for treating a genetic disorder, a wound, a burn, or a disease, or for effecting gene therapy in a recipient organism. Transgenic and chimeric organisms, and cells are also provided.
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