Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_916075766043ce900399a4c2eee9f054 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-12 |
classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12 |
filingDate |
1999-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2002-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_89b96453c6606e8d5545f83e961ec7d1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45bbdfcd2324f2eac4f53a0b644de8cf |
publicationDate |
2002-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-6451571-B1 |
titleOfInvention |
Thymidine kinase mutants |
abstract |
The present invention provides isolated nucleic acid molecules encoding a Herpesviridae thymidine kinase enzyme comprising one or more mutations, at least one of the mutations encoding an amino acid substitution upstream from a DRH nucleoside binding site which increases a biological activity of the thymidine kinase, as compared to unmutated thymidine kinase. Within another aspect, one of the mutations is an amino acid substitution within a DRH nucleoside binding site which increases a biological activity of the thymidine kinase, as compared to unmutated thymidine kinase. Also provided are vectors suitable for expressing such DNA molecules, as well as methods for utilizing such vectors. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110129344-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007134212-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9750823-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9701985-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7626075-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010075414-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006230467-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11542524-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7666639-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007212757-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9951114-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018005975-A1 |
priorityDate |
1994-05-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |