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filingDate 1993-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ff49faa4839f4b9b532daafb0167673
publicationDate 1994-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-9402107-A3
titleOfInvention Method and medicament for inhibiting neutrophil elastase and cathepsin g
abstract A method and medicament for the inhibition of neutrophil elastase and cathepsin G in mammals comprising administering a treatment effective amount of 2-O-desulfated heparin to a mammal in need thereof. The medicament preferably is administered by aerosolization or by intravenous (IV) injection. In specific embodiments of the invention, the ratio of 2-O-desulfated heparin to elastase is greater than about 0.2 and less than about 2.0, or the ratio of 2-O-desulfated heparin to cathepsin G is greater than about 0.4 and less than about 2.0. Preferably, the 2-0 desulfated heparin medicament includes a physiologically acceptable carrier which may be selected from the group consisting of physiologically buffered saline, normal saline, and distilled water.
priorityDate 1992-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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