Polysaccharide derivatives of heparin, heparan sulphate, fraction and fragments thereof, process for their preparation and pharmaceutical compositions containing them
The compounds device from heparin from which the -SO₃-groups of the amino sugar have been removed and replaced with acetyl. Subsequently the -SO₃-groups of iduronic acid were removed by controlled formation of epoxiden n and by stereo-selective splitting, with inversion of C₂-C₃ positions under mild and/or catalyst controlled conditions. n They are used in the treatment of cardiovascular disorders and in particular in the syndromes of disseminated vascular thromboses.