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filingDate 1993-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1993-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-9320104-A1
titleOfInvention Monoclonal antibodies against a carbohydrate-dependent epitope related to the v2 region of hiv-1 gp120
abstract New high affinity mAbs against gp120 of HIV-1 are described that are specific for a strong neutralization epitope cluster. The mAbs are specific for an amino acid sequence included in about amino acid 160 to about amino acid 180 of gp 120 of the HXB2 strain or in the homologous sequences of other strains. The binding of the mAbs to gp120 is carbohydrate dependent.
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