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filingDate 1999-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2003-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2003-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-6585979-B1
titleOfInvention HIV envelope polypeptides and immunogenic composition
abstract Oligonucleotide sequences encoding gp120 polypeptides from breakthrough isolates of vaccine trials using MN-rgp120 and the encoded gp120 polypeptides are provided. Use of the gp120 polypeptides from one or more of the isolates in a subunit vaccine, usually together with MN-rgp120, can provide protection against HIV strains that are sufficiently different from the vaccine strain (e.g.; MN-rgp120) that the vaccine does not confer protection against those strains. Antibodies induced by the polypeptides are also provided.
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