| abstract |
A variant of human Kunitz-type protease inhibitor domain III of tissue factor protease inhibitor (TFPI), the variant comprising the amino acid sequence (I) wherein X1 represents H or 1-5 naturally occurring amino acid residues except Cys, X2-X15 each independently represents a naturally occurring amino acid residue, and X16 represents OH or 1-5 naturally occurring amino acid residues except Cys, with the proviso that at least one of the amino acid residues X1-X16 is different from the corresponding amino acid residue of the native sequence. |