| abstract |
Human IL-3 variants or mutants are characterised in that one or more amino acids in or adjacent to the fourth predicted α-helix of hIL-3 and/or one or more amino acids in the first predicted α-helix of hIL-3 is/are replaced by another amino acid. These variants or mutants are useful in the modulation of profileration, differentiation or functional activation of haemopoietic cells or non-haemopoietic cells expressing or made to express the IL-3 receptor. |