| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_600db5b93a54999d3db277d10725d525
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bba842fc4d37dfcaced1b55bc0c91c7c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2400-50 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-1203
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-91
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-569
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K2-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-577
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-13 |
| filingDate |
1992-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_12d34c9e5b6692bd6d444d983127c608
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08094fd6044c160b11e2dda64d9a68d8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8750410902fcafe300cea77d40549012
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ccbf7a680dc2298bb52a144b50e78f9a |
| publicationDate |
1992-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-9216624-A1 |
| titleOfInvention |
Monoclonal antibody against lps core |
| abstract |
By use of the Köhler/Milstein procedure involving immunization of mice with a number of different rough strains of heat-killed Gram-negative bacteria followed by fusion and suitable screening of the resulting hybridomas, murine monoclonal antibodies are obtained which are cross-protective against endotoxemia caused by at least two different Gram-negative bacterial strains having different core structures. The murine MAbs may be chimerized or humanized by known methods. The preferred product is a chimeric MAb of IgG isotype in which the hypervariable regions of the heavy chain have the amino acid sequences: Asp Tyr Tyr Met Thr; Leu Ile Arg Asn Lys Arg Asn Gly Asp Thr Ala Glu Tyr Ser Ala Ser Val Lys; and Gln Gly Arg Gly Tyr Thr Leu Asp Tyr; the hypervariable regions of the light chain have the amino acid sequences: Arg Ala Ser Gln Asn Ile Asn Ile Trp Leu Ser; Lys Ala Ser Asn Leu His Thr; and Leu Gln Gly Gln Ser Tyr Pro Arg Thr; the framework regions in the variable domains are murine and the constant domains are human. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0151128-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0151128-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9913904-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7772372-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11168131-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108473559-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6749831-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8163552-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10117930-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7947812-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9943597-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017083515-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7741444-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-024697-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8741296-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9801938-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8562995-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010125565-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012136522-A1 |
| priorityDate |
1991-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |