| abstract |
The present application discloses the incorporation of specific membrane-associated proteins into enveloped vector particles to provide an altered host range for these viruses. As a model system, the incorporation of the VSV G protein into Moloney murine leukemia virus (MoMLV)-based retroviral vectors is disclosed. The application discloses methods of introducing genes using modified viruses, and the modified viruse's associated nucleic acid, proteins and cell lines. The methods of introducing genes are disclosed to be useful in a variety of gene therapy methods. |