abstract |
Uracil reductase inactivators, notably a 5-substituted uracil or 5,6-dihydro -5-substituted uracil, potentiate 5-fluorouracil and find use particularly in the treatment of cancer. The 5-substituent is selected from bromo, iodo, cyano, halo-substituted C1-4 alkyl, C2-6 alkenyl, 1-halo- C2-6 alkenyl and halo-substituted C2-6 alkynyl. |