| abstract |
Novel 5′-deoxy-cytidine derivatives represented by the general formula (I) n wherein R 1 is a hydrogen atom or a group easily hydrolyzable under physiological conditions; R 2 is a hydrogen atom, or —CO—OR 4 group [wherein R 4 is a saturated or unsaturated, straight or branched hydrocarbon group consisting of one to fifteen carbon atoms, or a group of the formula —(CH 2 ) n —Y (in which Y is cyclohexyl or phenyl; n is an integer from 0 to 4)]; R 3 is a hydrogen atom, bromo, iodo, cyano, a C 1-4 alkyl group [which may be substituted with halogen atom(s)], a vinyl or ethynyl group [which may be substituted with halogen atom(s), C 1-4 alkyl, cycloalkyl, aralkyl, or aromatic ring which may have one or more hetero atom(s)], or an aralkyl group which may be substituted for use in medical therapy, especially tumor therapy. |