| abstract |
The present invention relates to novel nitric acid esters of cyclohexanol derivatives of formula (I) in which A is a valency line or a C1?-C6? alkylene chain and B is the group -NR?1-CO-Z, -NR?1-SO2?-Z or -CO-NR?2-Z, where R?1 is hydrogen or a C1?-C6?-alkyl group, R?2 is hydrogen, a hydroxy, hydroxy-C1?-C6?-alkyl, C1?-C6?-alkoxy, C1?-C6?-alkyl, C2?-C6?-alkenyl or C2?C6?-alkinyl group and Z is hydrogen, a C1?-C6?-alkyl, C2?-C6?-alkenyl or C2?C6?-alkinyl group, which may be substituted once or several times by a hydroxy, C1?-C6?-alkylcarbonyloxy, C1?-C6?-alkoxy, halogen, cyano, carboxy, C1?-C6?-alkoxycarbonyl, -CO-NR?3R?4, mercapto, C1?-C6?-alkylcarbonyl mercapto group, or Z is a C3?-C6?-cycloalkyl group or a pyridine, N-oxypyridine, tetrazolyl or pyrrolidinone ring, or Z together with R?2 and the nitrogen atom to which Z and R?2 are bonded, form a heterocyclic ring which may additionally contain an oxygen, sulphur or nitrogen atom, whereby the heterocyclic ring with an additional nitrogen atom may be acylated, possibly on the nitrogen atom, by a C1?-C6?-alkylcarbonyl group, and if B is a -NR?1-CO-Z- group, Z may also be a C1?-C6?-alkoxy group, or if Z is a C1?-C6?-alkyl or C2?-C6?-alkenyl group substituted by a mercapto, C1?-C6?-alkylmercapto or C1?-C6?-alkylcarbonyl mercapto, the C1?-C6?-alkyl or C2?-C6?-alkenyl group may be additionally substituted by the NR?4/R?5 or a C1?-C4?-alkylcarbonyl group and R?3 and R?4 may be the same or different and mutually independently hydrogen, a C1?-C6?-alkyl group or R?3 and R?4 together with the nitrogen atom to which they are bonded form a heterocyclic ring, their optically active forms and physiological permissible salts, and medicaments containing these compounds. The invention also concerns processes for producing compounds of formula (I) and novel intermediate products. |