| abstract |
Novel lactone compounds having immunomodulatory and antitumor activities, pharmaceutical compositions comprising such compounds, methods for the preparation of the novel compounds and compositions and methods of their use for therapeutic purposes are described. The new lactone compounds have the structure according to formula (I), wherein: R = -H, -A, -CH2?-Q, -COA or -COZ, A = lower alkyl, Z = monocyclicaryl, Q = phenyl, tolyl or xylyl, X = -H, -A, -Z or -CH2?-Z, and Y = -H, -A, -Z, -CH2?-Z, -COA, -COZ, the acid-addition salts, the octahydro and 23,24-dihydro derivatives thereof. |