| abstract |
A method for preparing discodermolide and structurally related analogs of formula V in a first step by reacting a compound of formula I with an aldehyde compound of formula II to form a beta-hydroxyketone of formula III, in a second step by reacting a compound of formula III to form a 1,3-diol of the general formula of formula IV and in the third step by lactonization and deprotection of the protected groups. Further described are intermediates of formulas I, Ia, Ib, Ic, Id, III, IIIa, IV, IVa. |