| abstract |
Antigenic epitopes associated with the extracellular segment of the domain which anchors immunoglobulins to the B cell membrane are disclosed. These epitopes are present on IgA-bearing B cells but not the secreted, soluble form of IgA. The epitopes can be exploited for therapy and prophylaxis. For example, antibodies specific for the epitopes associated with the anchoring peptide encompassing the epitope domain of IgA can be used to increase secretory IgA production for the purposes of treating patients with infectious disesases and IgE-mediated allergic diseases. |