| abstract |
The invention relates to acryloyl substituted pyrrole derivatives of formula (I), wherein n is an integer of 1 to 5; each of R1? and R2?, which may be the same or different, is hydrogen, halogen, -CN, -NO2?, C1?-C4? alkyl, or a group (a), R3? is hydrogen, halogen, -CN, or -NO2?; each R4? is, independently, hydrogen or C1?-C4? alkyl; A is a bond, a group (b), or a group -NH-Het-CO-, wherein Het is a saturated or unsaturated pentatomic or hexatomic heteromonocyclic ring; and B is a group (c), (d), (e), (f), or (g), in which m is 1, 2 or 3 and each R5? is, independently, a C1?-C4? alkyl group, and pharmaceutically acceptable salts thereof, which are useful as antineoplastic agents. |