| abstract |
Compounds that are α-haloacryloyl derivatives of distamycin of the formula (I), wherein R 1 is a bromo or chloro atom; R 1 is a distamycin or distamycin-like backbone as disclosed herein; or their pharmaceutically acceptable salts, are cytotoxic agents, especially effective in the treatment of tumors, in excess of expressing the GSH / GST system, which are poorly treatable or even resistant to conventional antitumor therapy. |