| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cea72e2de3c0219165474e54e9842d16 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T436-19 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-573
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-86 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-573
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-86 |
| filingDate |
1989-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6374064902f9112e0be6afc951c70c01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_185d32a3715739c60036b1eca99a7c3a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b888a48c924a0fac1045e4600839d30b |
| publicationDate |
1990-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-9003577-A1 |
| titleOfInvention |
Immunoassays for catalytically-active, serine proteases |
| abstract |
Methods for detecting and/or quantifying catalytically-active, serine proteases in a biological fluid are disclosed. The methods are useful for measuring the active enzymes of the coagulation/fibrinolytic system and evaluating the system or components of the system as indicative of thrombosis-related disorders. The methods involve the combined use of halomethyl ketone probes having broad specificity for catalytically-active serine proteases and immunological reagents specific for serine proteases of particular types. The halomethyl ketone probes are active site specific; they are only incorporated into catalytically-active serine proteases. An antibody is used to provide specificity for the particular type of serine protease. By the combined active-site-specificity of the halomethyl ketone probes and the type-specificity of the antibody, the catalytically-active fraction of a particular serine protease is determined. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9305398-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5639593-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2259362-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0138560-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9305397-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0138560-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5545518-A |
| priorityDate |
1988-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |