| abstract |
A laminated composite for administering fentanyl transdermally that consists of a fentanyl-impermeable occlusive backing layer (11), and an adhesive fentanyl reservoir layer (12) comprising fentanyl dissolved in an amine-resistant polydimethylsiloxane that has a high diffusivity and poor solubility for fentanyl which enables the fentanyl to be released rapidly from the composite over a one day period with little residual fentanyl left in the reservoir thereafter. |