| abstract |
Disclosed in the present invention are a pegylated lipid, a preparation method therefor, a liposome containing the pegylated lipid, a pharmaceutical composition containing the liposome, a preparation thereof, and the use thereof, belonging to the field of drug delivery. The pegylated lipid of the present invention can be used for modifying a liposome, and the pegylated lipid can also be further modified and coupled with a targeting group and then used for modifying a liposome to obtain a liposome having the targeting group. Due to the presence of a long-chain PEG and the targeting group on the pegylated lipid, the modified liposome can not only effectively avoid being removed by the reticuloendothelial system in a human body, but can also realize a targeting function. Therefore, when the pegylated lipid-modified liposome delivers an active drug to cells or a patient, especially when delivering a nucleic acid drug and anti-tumor drug, the liposome can not only realize long circulation in vivo and improve a drug transportation rate, but also has a targeting function, so that the therapeutic effect of a drug is improved under a synergistic effect. |