| abstract |
The present disclosure features novel lipids and compositions comprising these lipids. Nanoparticle compositions contain novel lipids as well as other lipids such as phospholipids, structured lipids, and PEG lipids. Nanoparticle compositions additionally comprising therapeutic and/or prophylactic agents such as RNA can be used to deliver therapeutic and/or prophylactic agents to mammalian cells or organs, eg, to modulate polypeptide, protein or gene expression. |