abstract |
The present invention relates to the field of biotechnologies, and in particular, to an anti-ANGPTL3 antibody or an antigen-binding fragment thereof. According to the anti-ANGPTL3 antibody or the antigen-binding fragment thereof provided by the present invention, a complementarity determining region of a heavy chain variable region comprises CDR-H1 having an amino acid sequence as represented by SEQ ID No: 1, CDR-H2 having an amino acid sequence as represented by SEQ ID No: 2, and CDR-H3 having an amino acid sequence as represented by SEQ ID No: 3; a complementarity determining region of a light chain variable region comprises CDR-L1 having an amino acid sequence as represented by SEQ ID No: 4, CDR-L2 having an amino acid sequence as represented by SEQ ID No: 5, and CDR-L3 having an amino acid sequence as represented by SEQ ID No: 6. The antibody or the antigen-binding fragment thereof provided by the present invention can specifically recognize ANGPTL3. |