| abstract |
The present invention provides an antibody or antigen-binding fragment that binds to angiopoietin-like protein 3 (ANGPTL3) and inhibits or interferes with at least one activity thereof. The anti-ANGPTL3 antibody can be used to treat diseases or disorders related to ANGPTL3, such as hyperlipidemia, hyperlipoproteinemia and dyslipidemia, including hypertriglyceridemia, hypercholesterolemia and the like. In addition, the anti-ANGPTL3 antibody can be administered to a subject in need of prevention or treatment of a disease or disorder, including cardiovascular disease such as atherosclerosis and coronary artery disease, nonalcoholic steatohepatitis (NASH) , diabetes, obesity, etc. |