http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022100877-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1e08cc675189fe8399732beb54635eaa |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1688 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1611 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0043 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K33-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0058 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0014 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5192 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-12 |
| filingDate | 2021-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4dd345d41d31c0355c8c468fb5731dab |
| publicationDate | 2022-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2022100877-A1 |
| titleOfInvention | Method for preventing infections by respiratory viruses including sars-cov-2 through strengthening airway mucus function |
| abstract | This invention concerns the unexpected finding that stable nanoparticles of the calcium salt of inorganic polyphosphate (polyP) as well as soluble polyP (sodium salt) increase the expression of specific, anti-virally protective mucins involved in the physical -mechanical barrier function of the mucus layer on the epithelium. The most striking effect is shown by polyP nanoparticles with a narrow size of about 90 nm that matches the size of respiratory virus particles such as the corona virus SARS-CoV-2, and a chain length of approximately 40 phosphate units. Surprisingly, a synergistic effect on mucin expression is observed if these nanoparticles are applied in combination with the soluble polyP which, additionally, inhibits the binding of the receptor binding domain of the SARS-CoV-2 spike protein to its cellular receptor ACE2. Soluble Na-polyP alone is somewhat less active. The inventive narrow-sized polyP-nanoparticles that are synthesized in the presence of polyethylene glycol are stable and can be used as a component of a nasal spray or mouth rinse or spray, as well as a skin cream or spray. |
| priorityDate | 2020-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 285.