| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c27458f93ab61da32ab78ec35f1fa8e8 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2400-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2800-413
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-624 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5115
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K6-864
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-0283
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61Q19-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-671
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K6-17 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61Q19-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-67 |
| filingDate |
2015-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a2f31d60fcc45cf511ff2e8dac384639 |
| publicationDate |
2017-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2017319446-A1 |
| titleOfInvention |
Morphogenetically Active Amorphous Calcium Polyphosphate Nanoparticles Containing Retinol For Therapeutic Applications |
| abstract |
This invention concerns a calcium polyphosphate material consisting of amorphous nanoparticles with a diameter of approximately between about 45 nm to about 0.25 μm that displays a considerable hardness (elastic modulus) of about 1.3 GPa. The inventive noncrystalline and biodegradable material that is produced under mild conditions, at room temperature, is morphogenetically active and preferably induces bone formation and the expression of the marker gene for osteoblast activity, alkaline phosphatase. In a preferred aspect, the invention concerns a method for producing amorphous retinol/calcium-polyphosphate nanospheres (retinol/aCa-polyP-NS) that show several unexpected properties and can be used in the treatment or prophylaxis of a variety of dermatological conditions, including photoaging. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022100877-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114620699-A |
| priorityDate |
2014-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |