abstract |
The present invention relates to: a double-stranded oligonucleotide which can highly specifically and efficiently inhibit amphiregulin expression, preferably a double-stranded oligonucleotide comprising a sequence in the form of RNA/RNA, DNA/DNA or a DNA/RNA hybrid; and a use, of a double-stranded oligonucleotide structure and nanoparticles comprising the double-stranded oligonucleotide, for preventing or treating obesity. |