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filingDate 2020-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2021-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2021055679-A1
titleOfInvention Chimeric hemagglutinin protein and a vaccine composition comprising the same
abstract Provided is a chimeric hemagglutinin (HA) protein including an HA1 subunit and an HA2 subunit, in which the HA1 subunit is composed of a first domain derived from a parental HA1 subunit of a first subtype influenza virus and a second domain derived from a parental HA1 subunit of a second subtype influenza virus. The chimeric HA protein has improved thermal stability and can be used in a vaccine composition for preventing influenza virus infection. Also provided is a method of inducing an immune response against an influenza virus in a subject in need thereof that includes administering the chimeric HA protein to the subject, thereby conferring protection against the influenza virus infection on the subject.
priorityDate 2019-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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