| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_df874e3cf88adba3792dc9d5b5776180 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-713
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 |
| filingDate |
2020-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6e991eaa6045017027c8d613a1571e5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_933dbd83ea4773ae3d77eb6df0198cc5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_280be962c773ceffc9f24f307dc9d48e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d17d47234946ea30dc7cf12ac495618 |
| publicationDate |
2021-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2021048315-A1 |
| titleOfInvention |
Use of duox1 inhibitors for treating cancer |
| abstract |
The present inventors have demonstrated that it is possible to control the secretory profile and phagocytosis function of pro-inflammatory macrophages, notably after irradiation on injured sites, by silencing the expression of a tumor suppressor gene called DUOX1 (dual oxidase 1). They therefore propose to inhibit the expression of the DUOX1 gene or the activity of the DUOX1 enzyme in tumor-associated macrophages for inducing a strong anti-tumor effect. They also propose to combine this treatment with a radiotherapy treatment, as said treatment is potentiated when DUOX1 is inhibited. |
| priorityDate |
2019-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |