| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_942782ef91e65ecc67141721d44d38eb |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C309-35
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-675
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65616 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C309-35
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-675
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6561 |
| filingDate |
2019-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ef91413d3cecc75ea8e538eec6d1e27
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99cfe327659e4c0745ead12000cf9db0 |
| publicationDate |
2020-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2020222393-A1 |
| titleOfInvention |
Novel tenofovir alafenamide salt and preparation method therefor |
| abstract |
The present inventors have researched and made efforts to overcome the problems of currently commercially available tenofovir alafenamide hemifumarate, such as low water solubility and an oral absorption rate of only 1%, and to develop a novel salt form capable of enhancing a pharmacological effect. As a result, tenofovir alafenamide heminapadisylate having water solubility 240 times that of tenofovir alafenamide hemifumarate can be used as a therapeutic or preventive pharmaceutical composition that is useful for the treatment of HIV-1 infection and chronic hepatitis B. |
| priorityDate |
2019-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |