| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3b72bc0a2f48e9f1e5260dd9b0fae605 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H17-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7048 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H17-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 |
| filingDate |
2020-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d7ac3d18cebfbd50d9fa6b4d0af997f6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21309b9941ee2ad575384f05e4db6ff0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33061a1543d2f664ce391979c1448075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d92ab8f23e3daece1ea30340203b0b32 |
| publicationDate |
2020-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2020160443-A1 |
| titleOfInvention |
Antifungal agents with improved water solubility |
| abstract |
Methods for preparing a polyene macrolide antifungal with improved aqueous solubility. The method involves providing a polyene macrolide antifungal having a carboxylic acid group; activating the carboxylic acid group; introducing a primary amine to the activated polyene macrolide antifungal; reacting for a time sufficient to convert the carboxylic acid to an amide, and quenching the reaction, thus yielding a polyene macrolide amide or salt thereof. Also provided are water-soluble polyene macrolide derivatives. |
| priorityDate |
2019-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |