| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6c0e8d16adfed30a2231ba4b252c19aa |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4741
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-472 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-472
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14 |
| filingDate |
2019-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_730b0a4bb4013ad84fbadfe91e4febb9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a943e6a2c14fc944fefbbd1c29f07e0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ce939fc14db868e7d8847bc904b3b0e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b2060646b23b068b6ca792fbf98278a4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dac0cb5ae8ddae1a1ef564caaff82fa5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b51cd5fe1ad5274ca507f3959eebcfcb |
| publicationDate |
2020-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2020024719-A1 |
| titleOfInvention |
Use of berbamine dihydrochloride in preparation of ebola virus inhibitor |
| abstract |
Use of berbamine dihydrochloride in preparation of an Ebola virus inhibitor. An antiviral active compound having binding ability to EBOV-GPc1 is obtained by using an activated Ebola virus envelope glycoprotein (EBOV-GPcl) as a target and performing structure-based virtual screening, said compound being berbamine dihydrochloride. The berbamine dihydrochloride can achieve the effect of anti-Ebola virus infection by binding to the target protein EBOV-GPcl so as to specifically inhibit the entry of Ebola recombinant virus. The concentration for 50% of maximum effect (EC50) of berbamine hydrochloride against EBOV is 0.49 μM, indicating that berberamine dihydrochloride has a strong inhibitory effect on EBOV. |
| priorityDate |
2018-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |