| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6c0e8d16adfed30a2231ba4b252c19aa |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4741
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-472 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-472 |
| filingDate |
2018-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dac0cb5ae8ddae1a1ef564caaff82fa5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ce939fc14db868e7d8847bc904b3b0e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b2060646b23b068b6ca792fbf98278a4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b51cd5fe1ad5274ca507f3959eebcfcb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a943e6a2c14fc944fefbbd1c29f07e0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_730b0a4bb4013ad84fbadfe91e4febb9 |
| publicationDate |
2019-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-109125323-A |
| titleOfInvention |
Application of Berberamine Dihydrochloride in Preparation of Ebola Virus Inhibitor |
| abstract |
The invention discloses the application of berbamine dihydrochloride in the preparation of Ebola virus inhibitor. The invention takes the Ebola virus activated envelope glycoprotein (EBOV-GPcl) as a target, and obtains an antiviral active compound with the ability to bind with EBOV-GPcl through structure-based virtual screening, and the compound is dihydrochloride Berberamine. Berberamine dihydrochloride can specifically inhibit the entry of recombinant Ebola virus by binding to the target protein EBOV‑GPcl, and achieve the effect of anti-Ebola virus infection. The half-maximal effect concentration (EC50) of berberamine dihydrochloride against EBOV was 0.49 μM, indicating that berberamine dihydrochloride had a strong inhibitory effect on EBOV. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110314160-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115197231-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11654141-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114668773-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115197231-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114668773-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020024719-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021043234-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11357771-B2 |
| priorityDate |
2018-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |