| abstract |
The first problem to be solved by the present invention is to provide a novel technique for screening for components that are effective in suppressing the deterioration of collagen structures in a subject. To solve the first problem, the present invention provides a method for screening for components that suppress the deterioration of collagen structures due to hypoxic conditions and/or aging, the method being characterized by using, as an index, the effectiveness in reducing increases in collagen fiber bundle formation when a test component is added to a collagen-containing composition in which cells are dispersed, and the composition is incubated in hypoxic conditions. |