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filingDate 2019-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ca2d7d9665a0fae01696d0141601c72
publicationDate 2019-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2019217924-A1
titleOfInvention Methods for enhancing the bioavailability and exposure of a voltage-gated potassium channel opener
abstract In certain embodiments, the present disclosure is directed to methods and uses for treating seizure disorders in a human, wherein the methods and uses comprise orally administering a therapeutically effective amount of the voltage-gated potassium channel allosteric modulator, N-[4-(6-fluoro-3,4-dihydro-1H-isoquinolin-2-yl)-2,6-dimethylphenyl]-3,3- dimethylbutanamide (Compound A), to the human in need thereof, for example, under fed conditions. The present disclosure is further directed to various improved methods of therapy and administration of Compound A.
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