| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69b4de7d64ebafc368b849bca94eab18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bd4e093cdc7736586aa9bf033427a098 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-28 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-407
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-407
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-077
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-16 |
| filingDate |
2019-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0bc3378f8fdb09e1fd54f452706ba5c8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1680294a939d7851d82a7cf5affa8738
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc92080ca249d3f0cd3e686983631a8f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47ae122f553e08445f60ece9056463d6 |
| publicationDate |
2019-10-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2019189814-A1 |
| titleOfInvention |
Cell direct reprogramming method |
| abstract |
The purpose of this invention is to provide a method which uses a recombinant fusion polypeptide to produce hepatocyte-like cells from somatic cells by facilitating the expression of genes which are involved in cell differentiation, using. The inventors have provided a membrane-permeable peptide, a DNA-binding polypeptide which binds to a gene which is involved in cell differentiation, and a fusion polypeptide which includes a transcriptional activator. The inventors have also provided a method for producing hepatocyte-like cells from somatic cells by culturing somatic cells in a culture medium that contains said fusion polypeptide. |
| priorityDate |
2018-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |