| abstract |
The invention relates to a crystal form of melphalan hydrochloride and a preparation method and application thereof. The preparation method has the advantages of convenient operation, short reaction period, less organic solvent for reaction, thereby reducing environmental pollution of three wastes, mild and controllable reaction conditions, and yield of reaction products. High and high purity. The prepared crystal form can be used for the treatment of multiple myeloma, breast cancer, ovarian cancer, chronic lymphocyte and granulocyte leukemia, malignant lymphoma, multiple myeloma. |