| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d9de52bba13e16028dffa8775e3f3f28 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3519
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2330-30 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0041
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6903 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-50 |
| filingDate |
2018-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_634cd8a0a15d65567a04175a80cb7fa4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92bcfb97342b3acfc50348ad21d5a8cf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5626224c5ac1ea94266a8a1a1208d252 |
| publicationDate |
2019-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2019011059-A1 |
| titleOfInvention |
FUNCTIONAL NUCLEIC ACID PROTECTIVE CARRIER BASED ON DNA HYDROGEL, PREPARATION METHOD AND APPLICATION THEREOF |
| abstract |
The invention belongs to the technical field of biomedicine, and specifically discloses a functional nucleic acid protective carrier based on DNA hydrogel, which is self-assembled by a degradable high molecular polymer including a side chain modified DNA, a functional nucleic acid and a crosslinking agent. . Compared with the prior art, the DNA hydrogel of the invention can be self-assembled in situ in an aqueous solution to form particles of controlled size and uniform size, and the particles have good stability under physiological conditions and can effectively slow down nucleic acids. The enzyme degrades the functional nucleic acid encapsulated inside the DNA hydrogel, and does not require any transfection reagent such as a cation or a virus to efficiently deliver the functional nucleic acid into the cytoplasm, thereby achieving therapeutic effects and avoiding introduced cations. Or toxic side effects caused by transfection reagents such as viruses. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107281497-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107281497-A |
| priorityDate |
2017-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |