| abstract |
Through the fusicoccin compound according to the present invention represented by general formula (1A), PPI stabilization effect can be enhanced. [In the formula, Y represents a carbonyl group, a sulfonyl group, or a substituted or unsubstituted alkylene group; R 1 and R 2 are the same or different and represent a hydrogen atom or a hydroxyl group; R 3 represents a hydrogen atom, a substituted or unsubstituted aminoalkyl group, or a group represented by general formula (2) (In general formula (2), R 5 represents a hydrogen atom or a substituted or unsubstituted alkyl group; R 6 represents a hydrogen atom; R 5 and R 6 may be bonded and form a substituted or unsubstituted alkylene group; and the symbol * represents a bond.); R 4a represents a substituted or unsubstituted alkyl group, a substituted or unsubstituted (hetero)cycloalkyl group, a substituted or unsubstituted alkoxy group, a substituted or unsubstituted (hetero)aryl group, or a substituted or unsubstituted amino group; and the case of R 4a representing an epoxy group is excluded when Y is a carbonyl group, R 1 is a hydroxyl group, R 2 is a hydrogen atom, and R 3 is a group represented by general formula (2).] |