| abstract |
Provided are: a biological reaction device that reduces the stress and damage visited on microorganisms, etc., in a biological reaction, and enables a biological reaction in which microorganisms, etc., are used to be efficiently and economically performed; and a biological reaction method in which said biological reaction device is used. In order to reduce the stress and damage visited on microorganisms, etc., the amount per minute of a biological culture solution that is extracted from a culture tank and then returned to the culture tank after being admixed with micro-nano bubbles is set as at least 1% to less than 48% of the biological culture solution accommodated in the culture tank, and the decrease in the dissolved oxygen concentration associated therewith is compensated for by setting the oxygen partial pressure of the gas phase in the upper part of the biological culture solution in the culture tank to at least 0.23 atm to less than 0.6 atm and/or setting the pressure of the gas phase in the upper part of the biological culture solution in the culture tank to at least 1.1 atm to less than 3.0 atm. |