| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_550ee072e52995859dc71b7912101991 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-47 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| filingDate |
2016-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_13c2a535a64a615cd1526ac6069cdef7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a507b5da0fac82a5e71d0e22496f83f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e5a6717569a8bc0c1ec3812a6d61f68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b8fcef54728461ca46871e3bb4dcf230 |
| publicationDate |
2017-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2017201635-A1 |
| titleOfInvention |
Cellular expression of hyaluronidase and use thereof in solid tumour cell therapy |
| abstract |
Discosed is a free or transmembrane fusion protein hyaluronidase expressed by CAR-T cells or other cells. While maintaining the anti-tumour activity of CAR-T cells or other cells, the cell-expressed hyaluronidase thereof can degrade the hyaluronic acid in the extracellular matrix (ECM), reduce the viscosity of the hyaluronic acid, enhance the tissue permeability of ECM, and facilitate penetration of CAR-T cells or other cells into solid tumours and infiltration thereof in solid tumours, thereby enhancing the efficacy of CAR-T cells or other cells in the treatment of solid tumours. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023168305-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020119048-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022229412-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109913422-A |
| priorityDate |
2016-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |