| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24aca9ded2638ea793d05360dde7a4a0 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2330-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-572 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-572 |
| filingDate |
2017-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92a66e552455235a5f5e675ea029c447
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_363c667375b39423d803f61db932d49b |
| publicationDate |
2017-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2017188042-A1 |
| titleOfInvention |
Method for producing monomer for single-stranded nucleic acid molecule |
| abstract |
A compound represented by formula (3) or an enantiomer thereof, which is a monomer that can be used for the production of a single-stranded nucleic acid molecule capable of suppressing the expression of a target gene, can be produced by: reacting a compound represented by formula (1) or an enantiomer thereof with 6-hydroxyhexanoic acid in a solvent in the presence of an additive such as 1-hydroxybenzotriazol and a condensing agent; mixing the resultant reaction mixture with water and a base such as an alkali metal hydroxide to produce a compound represented by formula (2) or an enantiomer thereof; and reacting the compound represented by formula (2) or an enantiomer thereof with 2-cyanoethyl-N,N,N',N'-tetraisopropylphosphorodiamidite in a solvent in the presence of a coupling activator such as a diisopropylaminetetrazole salt. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020202952-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021153047-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020202949-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020202950-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112020507-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112020507-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019208571-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021153770-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020202953-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020202951-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022064908-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11401296-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021070494-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021162070-A1 |
| priorityDate |
2016-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |