| abstract |
The present invention provides a method for producing an antibody against a peptide, a protein, or the like to which immunotolerance is easily established, by using an antigen-binding molecule containing a domain that binds to a molecule expressed on the surface of a cell having a function for inhibiting an immune response and a domain that binds to a T cell receptor (TCR) complex. The present invention further provides a humoral immune response enhancer and a pharmaceutical composition containing the antigen-binding molecule as an active ingredient and intended for use in combination with a vaccine for treatment. |