| abstract |
The present invention provides a composition for alleviating skin wrinkles, containing a predetermined fusion protein as an active ingredient. The fusion protein comprises a growth hormone or a fragment thereof, and the Fc region of a modified immunoglobulin. The fusion protein, which is the active ingredient of the composition according to the present invention effectively inhibits matrix metallo proteinase-1 (MMP-1) generation or elastase activity so as to enable the degradation of collagen or elastin within dermal tissue to be minimized, thereby enabling a skin sagging phenomenon or skin wrinkle generation to be prevented or alleviated. Therefore, the composition according to the present invention can be utilized in a medicine, a cosmetic product, a personal care product and the like for skin antiaging, skin wrinkle alleviation, skin elasticity maintenance and the like. |