http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017066537-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_18d92c46f60af8af24e262b67381d7eb |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-154 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-658 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-25 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-543 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6825 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-543 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate | 2016-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e293f53bceb78ed39d173d83582eaed0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6a0bb916cb4c9f9eec7e78daeddce9e |
| publicationDate | 2017-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2017066537-A1 |
| titleOfInvention | Multiplexed detection of circulating tumor antigens and epigenetic markers using plasmon-enhanced raman spectroscopic assays |
| abstract | In one aspect, the present invention provides a new liquid biopsy tool for multiplex detection of a panel of circulating tumor antigens based on plasmon-enhanced spectroscopic imaging. The structured nanoprobes realize substantive signal amplification while the attached Raman reporter independently tailors the spectral response. Moreover, the nanoprobes of the present invention have the excitation and emission spectral signatures in the clear near infrared window and are designed to suppress both intimate contact (Raman) and through-space (fluorescence) enhancement of endogenous markers, and the inventive methods show high detection sensitivity. In another aspect, the present invention provides a new multiplex and ultrasensitive diagnostic platform by exploiting SERS signatures of nucleic acid molecules tagged specifically to circulating DNA fragments carrying tumor-specific alterations, which are methylated in certain disease states. Significantly, development of this platform will aid in sample conservation, reduce sample-handling requirements and lower overall cost and turn-around time. Methods of diagnosis and treatment using these methods are also provided. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111781376-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109337982-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115420727-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111781186-A |
| priorityDate | 2015-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 241.