abstract |
[Problem] To provide an external skin preparation solid substrate exhibiting high breaking strength and excellent thermal stability, and usable as a stick-shaped substrate or the like. [Solution] An external skin preparation solid substrate containing: a lipid-peptide-type compound comprising one or more types selected from among a compound represented by formula (1), a compound similar thereto, or a pharmaceutically usable salt thereof; a surfactant; water; and a C8-30 saturated or unsaturated monovalent alcohol. (In the formula, R 1 represents a C9-23 aliphatic group, R 2 represents a hydrogen atom or a C1-4 alkyl group that may have a C1 or C2 branched chain, R 3 represents a -(CH 2 ) n -X group, n represents a number from 1 to 4, and X represents an amino group, a guanidino group, a -CONH 2 group, or a five-membered or six-membered ring which may have 1 to 3 nitrogen atoms or a condensed heterocycle configured from the five-membered ring and the six-membered ring.) |