| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e071d18fea054bf8d1420d483e78ed1 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-22 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-365
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-22 |
| filingDate |
2016-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86745584d5e9a918a0b854db0b7a4a89
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8738403a79dbe58e6cae767ece0bd9dc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7941499387af3757e4d369c3b3bf678c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21576a4487ae1da5d45eccf70b5b6e0d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_676b15c0c3cfe35838f92d684fa5eef3 |
| publicationDate |
2016-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2016176560-A1 |
| titleOfInvention |
Chromium-mediated coupling and application to the synthesis of halichondrins |
| abstract |
The present invention provides unified synthesis of the CI -CI 9 building blocks of halichondrins and analogs theoreof using selective coupling of poly-halogenated nucleophiles in chromium-mediated coupling reactions. The present invention also provides a practical and efficient synthesis of C20-C38 building blocks of halichondrins and analogs thereof. Also provided herein are general methods of selective activation and coupling of poly-halogenated analogs with an aldehyde. The provided coupling reactions are selective for halo-enone and halo-acetylenic ketal over vinyl halide and halide attached to a sp hydridized carbon. The provided efficient selective coupling reactions can allow easy access to the CI -CI 9 building blocks and C20-C38 building blocks of halichondrins and analogs thereof with limited or no purification or separation of the intermediates. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10954249-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110831946-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108658956-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018187331-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110831946-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10556910-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019009956-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-I781163-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108341738-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019010363-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-7266267-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2794176-C2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9938288-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11220513-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11407762-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111566113-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11498892-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11155562-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019099646-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108658956-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10344038-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10392400-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11548898-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10633392-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11725015-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2018108937-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4119563-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108341738-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4169924-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10844073-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2019034923-A |
| priorityDate |
2015-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |